Cardiovascular actions ofDaucus carota
作者： A. H. Gilani , F. Shaheen , S. A. Saeed
DOI: 10.1007/BF02974250
关键词: Blood pressure 、 In vivo 、 Atropine 、 Norepinephrine (medication) 、 Endocrinology 、 Adrenergic receptor 、 Internal medicine 、 Thoracic aorta 、 Cholinergic 、 Pharmacology 、 Medicine 、 Diastole
摘要: Ethanolic extract ofDaucus carota (DC) at the dose of 10–100 mg/kg caused a dose-dependent fall in systolic and diastolic arterial, blood pressure normotensive anesthetized rats. These effects were not blocked by atropine (1 mg/kg) pretreatment withDC did alter pressor response to norepinephrine indicating that, cardiovascular ofDC are independent cholinergic or adrenergic receptors involvement. In spontaneously beating guinea-pig paired atria,DC induced a, concentration-dependent (0.3–5 mg/ml) decrease force rate atrial contractions. rabbit thoracic aorta,DC inhibition K+-induced contractions similar concentrations. results suggest that may exhibit Ca2+ channel blocking-like direct relaxant action on cardiac smooth muscle preparations this be responsible for its hypotensive effect observed thein vivo studies.
springer.com
sci-hub.se 参考文章(10)
Van Rossum Jm, Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Archives internationales de pharmacodynamie et de thérapie. ,vol. 143, pp. 299- 330 ,(1963)
T B Bolton, Mechanisms of action of transmitters and other substances on smooth muscle. Physiological Reviews. ,vol. 59, pp. 606- 718 ,(1979) , 10.1152/PHYSREV.1979.59.3.606
Maurice Wibo, R. Miller, Theophile Godfraind, Calcium antagonism and calcium entry blockade. Pharmacological Reviews. ,vol. 38, pp. 321- 416 ,(1986)
Janet Brown, John C. Doxey, Sheila Handley, Effects of α-adrenoceptor agonists and antagonists and of antidepressant drugs on pre-and postsynaptic α-adrenoceptors European Journal of Pharmacology. ,vol. 67, pp. 33- 40 ,(1980) , 10.1016/0014-2999(80)90005-9
Hideaki Karaki, George B. Weiss, Calcium release in smooth muscle. Life Sciences. ,vol. 42, pp. 111- 122 ,(1988) , 10.1016/0024-3205(88)90674-1
S. Anwar-ul, H. Gilani, L. B. Cobbin, The cardio-selectivity of himbacine: a muscarine receptor antagonist. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 332, pp. 16- 20 ,(1986) , 10.1007/BF00633191
O. ARUNLAKSHANA, H. O. SCHILD, Some quantitative uses of drug antagonists British journal of pharmacology and chemotherapy. ,vol. 14, pp. 48- 58 ,(1997) , 10.1111/J.1476-5381.1959.TB00928.X
Anwar-Ul-Hassan Gilani, Antihypertensive activity of himbacine in anesthetized cats Drug Development Research. ,vol. 24, pp. 127- 133 ,(1991) , 10.1002/DDR.430240111
S. A. H. Gilani, L. B. Cobbin, Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Archives internationales de pharmacodynamie et de thérapie. ,vol. 290, pp. 46- 53 ,(1987)
A. K. Nadkarni, K. M. Nadkarni, Indian materia medica ,(1955)