Glutathione Peroxidase 2, a Selenoprotein Exhibiting a Dual Personality in Preventing and Promoting Cancer

摘要: GPx2 is mainly expressed in the intestine but also up-regulated several cancer types. Being a selenoprotein and target of transcription factor Nrf2, it was first proposed to protect from tumor development. However, turned out that picture much more complex. not only regulated by β-catenin Wnt pathway, ΔNp63, NKX3.1, which are pathways involved regulation proliferative survival processes. Accordingly, found enhance proliferation inhibit apoptosis. These important functions required maintain homeostasis healthy intestine. acting cells, they will promote progression disease, as confirmed models decrease development Gpx2 knockout mice. In contrast, if carcinogenesis driven inflammation, rather acts protective. The recent identification STAT3 an additional inducing might explain up-regulation inflammation point role tissue regeneration wound healing. Thus, accordance with different regulating its expression, can act anti- pro-carcinogenic depending on model stage cancer. Whereas initiation, supports growth, cell has been established.