Characterization of Hematopoietic Cells Transformed In Vitro by AEV-H, a v-erb B-Containing Avian Erythroblastosis Virus

摘要: Avian erythroblastosis virus ES4 (AEVES4) is a replication-defective avian leukemia that causes erythroleukemia and fibrosarcomas in chicks transforms bone marrow cells fibroblasts vitro (for review, see [7]). The 5.5 kb genome of AEV-ES4 contains two oncogenes, v-erbA v-erbB [1, 5, 21] which code for gagrelated cytoplasmic protein, p75gag_erbA, an integral membrane glycoprotein, gp74erbB, respectively [10–12, 18]. Studies using deletion mutants either or indicate sufficient to transform erythroblasts, whereas does not by itself but cooperates with erythroblasts generate more transformed phenotype [6, 7, 20].