Base-catalyzed one-pot synthesis of dispiro-1,3-dioxolane bisoxindoles from N-methylisatin and methyl propiolate
作者： Su Yeon Kim , Hwa Jung Roh , Da Young Seo , Ji Yeon Ryu , Junseong Lee
DOI: 10.1016/J.TETLET.2017.01.055
关键词: Diastereomer 、 One-pot synthesis 、 Cascade reaction 、 Medicinal chemistry 、 Chemistry 、 Dioxolane 、 Oxyanion 、 Isatin 、 Reaction mechanism 、 Acetylide 、 Stereochemistry
摘要: Abstract Base-catalyzed domino reaction between N-methylisatin and methyl propiolate afforded four diastereomeric dispiro-1,3-dioxolane bisoxindoles. The mechanism involved sequential 1,2-addition of acetylide anion to the carbonyl group isatin, resulting oxyanion a second molecule final 5-exo-dig cyclization process.
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