Protein-coding Genes And Long Noncoding Rnas Are Differentially Expressed In Dasatinib-treated Chronic Myeloid Leukemia Patients With Resistance To Imatinib
作者： Rosana A Silveira , Angela A Fachel , Yuri B Moreira , Carmino A De Souza , Fernando F Costa
DOI: 10.1179/1607845413Y.0000000094
关键词: Imatinib 、 Immunology 、 Biology 、 Cancer research 、 Myeloid leukemia 、 Gene regulatory network 、 Gene expression 、 Dasatinib 、 Gene 、 DNA microarray 、 Carcinogenesis
摘要: Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some also develop dasatinib. To identify potential molecular pathways involved primary dasatinib CML, we analyzed gene expression profiles of mononuclear cells 7 imatinib-resistant patients, collected before and after 1-year treatment. Large-scale was measured Agilent microarrays covering protein-coding genes long (>200 nt) noncoding RNAs (lncRNAs). Sets lncRNAs significantly differentially expressed (>1.5 fold-change; q value ≤10%) were identified. Ingenuity Pathway Analysis pointed a number functions, canonical networks that enriched genes. In addition genes, have been recently implicated leading tumorigenesis. Our data point new possible regulatory elements CML.
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