Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study.
作者： Glenn Liu , Hope S. Rugo , George Wilding , Teresa M. McShane , Jeffrey L. Evelhoch
关键词: Angiogenesis inhibitor 、 Area under the curve 、 Angiogenesis 、 Dosing 、 Dynamic contrast 、 Medicine 、 Nuclear medicine 、 Pharmacodynamics 、 Disease Response 、 Magnetic resonance imaging
摘要: Purpose Identifying suitable markers of biologic activity is important when assessing novel compounds such as angiogenesis inhibitors to optimize the dose and schedule therapy. Here we present pharmacodynamic response acute dosing AG-013736 measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Patients Methods Thirty-six patients with advanced solid tumors were treated various doses AG-013736. In addition standard measures objective disease pharmacokinetic analysis, DCE-MRI scans acquired at baseline repeated cycle 1—day 2 after scheduled morning in 26 patients. Indicators a vascular response, volume transfer constant (Ktrans) initial area under curve (IAUC), calculated assess effect treatment on tumor function. Results Evaluable data obtained 17 (65%) A linear correlation was found which percentage change fr...
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