Modeling Breast Cancer Heterogeneity With Patient-Derived Xenografts

摘要: Abstract To better understand the biology underlying breast cancer progression and improve development application of therapies, it is essential to model heterogeneity inherent cancer. The ability graft patient tumor fragments into immune-deficient mice enabling relatively large collections unique models. Several different techniques, including orthotopic heterotopic implantations, are being used generate patient-derived xenograft (PDX), consensus across techniques that molecular phenotypic traits exhibited by tumors for most part maintained in xenografts, although some genetic drift has been reported. At present, pools PDXs preclinical testing, coming years will illuminate whether use enables broader testing increased therapeutic success.