Potensi Daun Kayu Bawang (Protium javanicum) sebagai Penghambat Kerja Enzim Tirosinase
作者： Morina Adfa , Irmanida Batubara
DOI:
关键词: Protium javanicum 、 Chemistry 、 Tyrosinase 、 Tyrosinase inhibitor 、 Organic chemistry 、 Methanol 、 Melanin 、 Potency 、 Food science 、 Water fraction
摘要: Utilization of Kayu Bawang (Protium javanicum) plant is needed beside its utilization for building material, especially the leaves which easily to get. The aim this research was describe potency as tyrosinase inhibitor, an enzyme responsible synthesis melanin natural color skin. macerated with methanol. methanol extract then partitioned n-hexane, EtOAc, n-BuOH, and water. All fractions were concentrated tested ability inhibit two substrates namely L-DOPA (diphenolase reaction) L-tyrosine (monophenolase reaction). result showed that n-hexane fraction could diphenolase reaction IC 50 value 114.2 ppm. EtOAc monophenolase (IC 834.0 ppm). Methanol extract, n-BuOH fraction, water not activities. conclusion nonpolar semi polar compounds in be utilized whitening agent.
参考文章(9)
E Deharo, G Bourdy, C Quenevo, V Muñoz, G Ruiz, M Sauvain, A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians. Journal of Ethnopharmacology. ,vol. 77, pp. 91- 98 ,(2001) , 10.1016/S0378-8741(01)00270-7
Kosei Yamauchi, Tohru Mitsunaga, Irmanida Batubara, Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica Natural Resources. ,vol. 02, pp. 167- 172 ,(2011) , 10.4236/NR.2011.23022
Morina Adfa, Yosuke Hattori, Masayuki Ninomiya, Yasuhiro Funahashi, Tsuyoshi Yoshimura, Mamoru Koketsu, None, Chemical constituents of Indonesian plant Protium javanicum Burm. f. and their antifeedant activities against Coptotermes formosanus Shiraki. Natural Product Research. ,vol. 27, pp. 270- 273 ,(2013) , 10.1080/14786419.2012.665917
Morina Adfa, Tsuyoshi Yoshimura, Kenichi Komura, Mamoru Koketsu, None, Antitermite Activities of Coumarin Derivatives and Scopoletin from Protium javanicum Burm. f. Journal of Chemical Ecology. ,vol. 36, pp. 720- 726 ,(2010) , 10.1007/S10886-010-9807-1
I. Batubara, L.K. Darusman, T. Mitsunaga, M. Rahminiwat, E. Djauhari, Potency of Indonesian Medicinal Plants as Tyrosinase Inhibitor and Antioxidant Agent Journal of Biological Sciences. ,vol. 10, pp. 138- 144 ,(2010) , 10.3923/JBS.2010.138.144
Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo, Inhibitory Effect of Artocarpanone from Artocarpus heterophyllus on Melanin Biosynthesis Biological & Pharmaceutical Bulletin. ,vol. 29, pp. 1966- 1969 ,(2006) , 10.1248/BPB.29.1966
Te-Sheng Chang, An Updated Review of Tyrosinase Inhibitors International Journal of Molecular Sciences. ,vol. 10, pp. 2440- 2475 ,(2009) , 10.3390/IJMS10062440
I. Batubara, L.K. Darusman, T. Mitsunaga, H. Aoki, M. Rahminiwat, E Djauhari, K. Yamauchi, Flavonoid from Intsia palembanica as skin whitening agent. Journal of Biological Sciences. ,vol. 11, pp. 475- 480 ,(2011) , 10.3923/JBS.2011.475.480
Kittisak Likhitwitayawuid, Stilbenes with tyrosinase inhibitory activity Current Science. ,vol. 94, pp. 44- 52 ,(2008)