Wnt-1 signal as a potential cancer therapeutic target.

摘要: Wnt-1 was first identified as a proto-oncogene activated in mouse mammary tumors induced by tumor virus 1982. signal is secreted glycoprotein that plays important roles embryonic development and carcinogenesis. In conditional transgenic model, reduction of signaling results the regression initiated primary lung metastasis. Aberrant activation Wnt pathway has been strongly linked to human cancers. Increased found variety Our group shown blockade signaling, either small interference RNA or anti-Wnt-1 antibody induces apoptosis cancer cells inhibits growth vivo. This review summarizes recent significant findings potentials new therapeutic target for cancer.