The role of gastric secretagogues in regulating gastric histamine release in vivo.

摘要: The effect of short-term intragastric arterial infusion pentagastrin and methacholine on histamine N tau-methyl secretory rates was evaluated in mongrel dogs vivo. Doses were chosen that stimulate gastric acid secretion equivalently. Histamine by measuring the venous plasma concentrations at several time points during secretagogue infusion, blood flow continuously monitored. analyzed stable isotope dilution technique using gas chromatography/negative ion-chemical ionization mass spectrometry. calculated subtracting from multiplying difference flow. Infusion resulted large pulsed increase release 1.5 +/- 0.7 ng/min 0 to 72 20 5 minutes, which decreased a plateau 8 minutes. tau-Methyl rate increased 6.7 1.9 baseline maximum 42.5 13.1 10 maintained for duration infusion. Methacholine associated with small but sustained release, 1.6 0.6 5.9 1.7 unchanged methacholine. Gastric changes roughly paralleled extent is vasodilator its own right. Our data indicate much more effective stimulator than overall role gastrin-stimulated output likely be different cholinergic-mediated output.