Biopharmaceutics of Drugs Administered in Lipid-Containing Dosage Forms I: GI Absorption of Griseofulvin from an Oil-in-Water Emulsion in the Rat

摘要: The GI absorption characteristics of micronized griseofulvin from an oil-in-water emulsion dosage form, oil suspension, and aqueous suspension were assessed in the rat. Although there was a slight delay time occurrence peak plasma concentration following its oral administration emulsion, this form produced mean antibiotic level 1.5 2.3 times higher than suspensions, respectively. In addition, significantly increased over which concentrations drug maintained above 1 mcg./ml. All six rats dosed with attained 1-mcg./ml. or greater (mean duration 7.5 hr.), while only two out (duration 3.7 4.0 hr., respectively) four 3.9 hr.) ever achieved concentration. Based on area under versus curve measurements, it established that bioavailability can be 2.5-fold, as compared to by orally administering relatively water-insoluble form.