Immunosuppressive Activity of Buxidin andE-Buxenone fromBuxus hyrcana
作者： M Ahmed Mesaik , Sobia A Halim , Zaheer Ul‐Haq , M Iqbal Choudhary , Salma Shahnaz
DOI: 10.1111/J.1747-0285.2009.00906.X
关键词: Respiratory burst 、 Active site 、 In vitro 、 Interleukin 2 、 Pharmacology 、 Cytokine 、 Docking (molecular) 、 Interleukin 4 、 Chemotaxis 、 Biology 、 Molecular medicine 、 Biochemistry
摘要: Buxidin (1) and E-Buxenone (2), steroidal alkaloids from Buxus hyrcana, are found to possess potent immunosuppressive properties. The activity was tested in vitro on oxidative burst, chemotaxis, T-cell proliferation, cytokine production. Both compounds showed a significant immunomodulatory with clear suppressive effect burst chemotaxis dose-dependent manner. They also exhibited the phytohemagglutinin-stimulated proliferation. further confirmed by suppression of IL-2 IL-4 Furthermore, molecular docking studies were performed investigate binding mode (2) IL-2. Despite structural differences between results revealed that they adopt similar pattern at active site A good agreement practical theoretic indicates current study could provide an alternate tool for optimization recently identified ligand as more inhibitors.
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