Preparation of Large Porous Deslorelin-PLGA Microparticles with Reduced Residual Solvent and Cellular Uptake Using a Supercritical Carbon Dioxide Process
作者： Kavitha Koushik , Uday B. Kompella
DOI: 10.1023/B:PHAM.0000019308.25479.A4
关键词: Organic solvent 、 Plga microparticles 、 Porosity 、 Chemical engineering 、 Deslorelin 、 Residual solvent 、 Chemistry 、 Supercritical fluid 、 Supercritical carbon dioxide 、 Scientific method 、 Chromatography
摘要: Purpose. The purpose of this study was to prepare large-porous peptide-encapsulating polymeric particles with low residual solvent that retain deslorelin integrity, sustain drug release, and exhibit reduced epithelial macrophage uptake. We hypothesized supercritical carbon dioxide (SC CO2) pressure-quench treatment microparticles prepared using conventional approach expands these extracts the organic solvent.
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