Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

摘要: Steatosis is a common histopathological feature of chronic hepatitis B (CHB) and has been associated with severity liver disease. Recently, the rs738409 I148M patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism demonstrated to influence steatosis susceptibility fibrosis progression in patients different diseases, but no data are yet available for CHB. The aim this study was evaluate whether PNPLA3 influences large series We enrolled 235 treatment-naive CHB consecutively examined by percutaneous biopsy. In ≥2-cm-long tissue cores, were staged Kleiner METAVIR scores, respectively. determined Taqman assays. present 146 (62%) patients, whom 24 (10%) had severe (>33% hepatocytes) steatosis. independently age (odds ratio [OR]: 2.67; confidence interval [CI]: 1.50-4.92; ≥50 years), body mass index (BMI; OR, 2.84; CI, 1.30-6.76; BMI ≥27.5 kg/m2), diabetes or impaired fasting glucose (OR, 4.45; 1.10-30.0), 148M allele 1.62; 1.00-7.00; each allele). Independent predictors 3.60; 1.39-9.22; kg/m2) 6.03; 1.23-5.0; alleles progressive increase acquired cofactors, such overweight history alcohol intake (P = 0.005). Conclusion: and, particular, when intake, (Hepatology 2013;58:1245–1252)