Genomic structure of the human CD53 gene
作者： Vladimír Kořínek , Václav Hořejší
DOI: 10.1007/BF00188803
关键词: Biology 、 Gene cluster 、 Genetics 、 Promoter 、 Exon 、 Gene 、 Complementary DNA 、 genomic DNA 、 Nucleic acid sequence 、 Homology (biology)
摘要: The genomic structure of the gene encoding human pan-leukocyte surface glycoprotein CD53 (a member “tetraspan family” membrane proteins) was determined. consists eight exons all sequences found in cDNA and is spread over more than 26 kilobases DNA. exon-intron organization strikingly similar to CD63 TAPA-1 genes, which suggests a close evolutionary relationship between these genes. 5′ end upstream first exon contains at least three transcription start points (approximately 20 base pairs published cDNA). region initiation sites not G+C rich; it potential binding for several transcriptional factors but no TATA or CCAAT boxes.
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