Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer

摘要: Memory T cells survive for months and even years are critical host defense in humans. They have been recently suggested to play a significant role tumor immunity. In this study, we aimed investigate the clinical impact of tumor-infiltrating memory on human gastric cancer. We evaluated CD45RO(+)T infiltrating into primary cancer tissues by immunohistochemistry 101 patients with Patients were classified 2 groups (CD45RO(+Hi) CD45RO(+Lo)) based number positively stained cells. There was no correlation observed between CD45RO status post-operative prognosis early By contrast, advanced cancer, overall disease-free survival CD45RO(+Hi) significantly improved compared those CD45RO(+Lo). addition, tumors correlated development recurrence, particularly peritoneal recurrence. Furthermore, local expression interferon-γ (IFN-γ) higher than that CD45RO(+Lo) tumors, suggesting CD45RO(+) induced immune activation. Multivariate analysis indicated an independent prognostic factor conclusion, functional value Our data suggest adaptive response is clinically