Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
作者： Peipei Liu , Jinliang Huang , Qian Zheng , Leiming Xie , Xinping Lu
DOI: 10.1007/S13238-017-0448-9
关键词: Translocase of the inner membrane 、 Cell biology 、 Biology 、 Non-coding RNA 、 RNA 、 Mitochondrial carrier 、 Genetics 、 MT-RNR1 、 Intermembrane space 、 Translocase of the outer membrane 、 Mitochondrial intermembrane space
摘要: Mammalian mitochondrial genome encodes a small set of tRNAs, rRNAs, and mRNAs. The RNA synthesis process has been well characterized. How the RNAs are degraded, however, is poorly understood. It was long assumed that degradation happens in matrix where transcription translation machineries reside. Here we show contrary to assumption, mammalian occurs intermembrane space (IMS) IMS-localized RNASET2 enzyme degrades RNAs. This provides new paradigm for understanding metabolism transport.
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