Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Cyclooxygenases, and the Cell Cycle

作者: Basil Rigas , Steven J. Shiff

DOI: 10.1007/978-1-4615-4149-3_13

关键词: Incidence (epidemiology)Cell cycleColorectal cancerCell cycle phaseMembrane proteinPathogenesisAnti-inflammatoryMedicineCancer researchAberrant crypt foci

摘要: Elucidating the pathogenesis of colon cancer, one commonest fatal malignancies in Western world, represents an important challenge for biomedical science. The seminal observation that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce incidence and mortality from colorectal cancer1 has ushered a new approach to study cancer.

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