Nitro-aspirin inhibits MCF-7 breast cancer cell growth: Effects on COX-2 expression and Wnt/β-catenin/TCF-4 signaling
作者： Niharika Nath , Rashida Vassell , Mitali Chattopadhyay , Marsel Kogan , Khosrow Kashfi
DOI: 10.1016/J.BCP.2009.06.104
关键词:
摘要: Abstract There is current evidence implicating the Wnt/β-catenin/TCF pathway in breast cancer. We investigated effect of para - and meta -positional isomers nitric oxide-releasing aspirin (NO-ASA), (ASA) on MCF-7 human cancer cell growth β-catenin/TCF signaling. The p m -NO-ASA strongly inhibited transcriptional activity compared to ASA; IC 50 s for inhibition were 57 ± 4, 193 ± 10 >5000 μM, they 12 ± 1.8, 75 ± 6.5 >5000 μM -, ASA, respectively. reduced expression Wnt/β-catenin downstream target gene cyclin D1 , total cellular β-catenin levels. COX-2 was induced by -NO-ASA, protein kinase C inhibitors reversed this induction. blocked cycle transition at S G 2 /M phase. These studies suggest a targeted chemopreventive/chemotherapeutic potential NO-ASA against
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