Acquisition of conditioned avoidance response in rats under the influence of addicting drugs

摘要: Four groups of white rats, aged 8–12 weeks, were treated with morphine, d-lysergic acid diethylamide, dl-amphetamine and ethanol, respectively, while being trained in a conditioned avoidance response (CAR) schedule. Morphine caused deterioration the acquisition CAR, as manifested by significant increases number training sessions required for 100% correct CAR reaction time (RT), when compared to those control group. The RT decreased after withdrawal morphine was associated revival emotional responses (CER). LSD ethanol insignificantly retarded RT, error CER. Amphetamine facilitated rate increased CER; during withdrawal, CER negligible whereas significantly. In another series tolerance seen and, less extent, amphetamine days continued treatment; effects lasted 3–4 only. These addicting drugs on learning are discussed light their influence animals degree development drug-dependence.