Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
作者： A. S. Wahl , W. Omlor , J. C. Rubio , J. L. Chen , H. Zheng
关键词: Rehabilitation 、 Stroke 、 Forelimb 、 Motor control 、 Forebrain 、 Spinal cord 、 Neurite 、 Corticospinal tract 、 Neuroscience 、 Medicine
摘要: The brain exhibits limited capacity for spontaneous restoration of lost motor functions after stroke. Rehabilitation is the prevailing clinical approach to augment functional recovery, but scientific basis poorly understood. Here, we show nearly full recovery skilled forelimb in rats with large strokes when a growth-promoting immunotherapy against neurite growth-inhibitory protein was applied boost sprouting new fibers, before stabilizing newly formed circuits by intensive training. In contrast, early high-intensity training during growth phase destroyed effect and led aberrant fiber patterns. Pharmacogenetic experiments identified subset corticospinal fibers originating intact half forebrain, side-switching spinal cord innervate impaired limb restore function.
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