Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance.
作者： H Lage , H Helmbach , M Dietel , D Schadendorf
关键词: Cancer research 、 Drug resistance 、 DNA topoisomerase II activity 、 Melanoma 、 Cisplatin 、 Biology 、 DNA 、 Enzyme inhibitor 、 Etoposide 、 Topoisomerase 、 Biochemistry
摘要: The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up tenfold reduced Topo II activity corresponding increasing degree drug resistance indicating that modulation contribute the phenotype. reduction reflected by decreased nuclear amounts both isoforms. © 2000 Cancer Research Campaign
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