Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

摘要: Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, alterations the gut microbiota. Mucosal-associated invariant T (MAIT) which innate-like cells that recognize bacterial ligands, present in blood enriched mucosal inflamed tissues. Here, we analyzed MAIT adipose tissues patients T2D and/or severe obesity. We determined circulating cell frequency was dramatically decreased both patient groups, this population even undetectable some obese patients. Moreover, displayed an activated phenotype elevated Th1 Th17 cytokine production. In patients, were more abundant tissue than exhibited a striking IL-17 profile. Bariatric surgery not only improved their metabolic parameters but also increased at 3 months after surgery. Similarly, production by strongly This study reveals profound abnormalities harboring disorders, suggesting potential role these pathologies.