Microbiome Analysis: Trends in Cancer Epidemiology, Challenges and Opportunities

摘要: Analysis of microbiome sampled from a given cancer site can yield information that may serve as prognostic exposure, risk, disease progression, and treatment response. We reviewed available published literature, grants funded by the National Cancer Institute’s Division Control Population Sciences to identify trends areas for future research. The incorporation analysis in epidemiologic studies is providing some promising insights into risk stratification. However, our identified several knowledge gaps this emerging field: 1. Limited evidence stability different biospecimen types over time at temperatures analysis, 2. software reliably standardizes sequencing data platforms corrects biases against rare or unrepresented taxa, 3. Harmonization methods used across research centers. 4. Surrogate markers will be useful monitoring progression infection development, 5. Time-varying natural history cancers order key microbiota shifts community structure, 6. Determining whether cause effect outcomes. If these are addressed, likely provide field with new approaches early diagnosis help develop more effective preventative measures.