hsa‐miR‐210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer

摘要: BACKGROUND: Hypoxia is an important mechanism of treatment resistance in head and neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs frequently dysregulated cancer. The authors have investigated the role 3 microRNAs, including hypoxia-induced hsa-miR-210, as potential markers hypoxia or prognosis. METHODS: Three hypoxia-related hsa-miR-21, hsa-miR-10b, were measured 46 samples from patients with HNSCC. Expression levels correlated clinicopathological variables other hypoxia: a published 99-gene metagene, individual genes such TWIST1, immunohistochemical expression hypoxia-inducible factor 1 its target gene carbonic anhydrase 9. We then performed survival analyses to investigate prognostic significance these microRNAs. RESULTS: Only level hsa-miR-210 was significantly hypoxia, metagene (rho = 0.67, P < .001). found no association between hsa-miR-10b tumor size, differentiation, stage. However, high associated locoregional disease recurrence (P .001) overall .008). hsa-miR-21 had significance. CONCLUSIONS: Expression cancer correlates approaches for assessing prognosis. This warrants further study classification marker therapies involving modulation hypoxia. Cancer 2010. © 2010 American Society.