Contrast-enhanced B-mode US angiography in the assessment of experimental in vivo and in vitro atherosclerotic disease.

摘要: Rationale and Objectives. This study was performed to (a) test the hypothesis that filling arterial lumen with echoes at B-mode ultrasound (US) enables assessment of wall luminal abnormalities (b) compare contrast material—enhanced US color power Doppler angiography. Materials Methods. Atherosclerotic lesions were created in 14 rabbit aortas imaged before after intravenous administration 0.3 mL AF0150, a agent. In addition, four replicas diseased human carotid arteries immersed tissue-mimicking phantom 1 AF0150 per liter porcine blood. Radiopaque plastic casts contact radiographs served as standards. Results. Although allowed immediate localization lumen, precise estimation stenoses reliable visualization surface irregularities not possible. After administration, angiogram-like images US, allowing rapid entire vessel wall. Consequently, more accurately measured than unenhanced (r2 = 0.94, P Conclusion. Microbubbles fill creating an image. The ability visualize inner outer surfaces vascular improved evaluation abnormalities.