Perfluorocarbon-enhanced sonography: value in detecting acute venous thrombosis in rabbits.

摘要: We have previously shown that perfluorocarbon emulsions administered i.v. act as contrast material during sonography by creating moving echoes in veins. Accordingly, we performed a study on rabbits designed to establish the value of perfluorocarbon-enhanced detecting acute venous thrombi.Constriction inferior vena cava (IVC) just above renal veins was established surgically 15 rabbits. Thrombus induced IVC 10 these; other five served controls. Gray-scale and color Doppler were before after infusion 3 ml/kg perflubron emulsion (formulation AF0102, Alliance Pharmaceutical, San Diego, CA). Sonograms evaluated for presence extent thrombus. Three additional with percutaneously thrombosis studied administration 0.2 ml preparation microbubbles gas PRD002, Pharmaceutical). In these animals thrombi con...