The Impact of Prophylactic Salpingo-oophorectomy on Health in Women who carry a BRCA1 or BRCA2 Mutation

摘要: Prophylactic salpingo-oophorectomy, the preventive removal of ovaries and fallopian tubes, is recommended to women who carry a BRCA1 or BRCA2 mutation in order reduce risk breast, ovarian tube cancer. The short long term health quality life effects this procedure are not well understood. We examined actual perceived reduction cancer associated with surgery. impact prophylactic salpingo-oophorectomy on health-related life, psychological distress, worry, menopausal symptoms, sexual function during year following surgery was also evaluated. In our prospective study, an 80% risk. residual for primary peritoneal 0.2% per 4.3% at 20 years after salpingo-oophorectomy. Most accurately their breast However, overestimated, particularly by mutation. Physical mental did decrease surgery; distress similar levels experienced general population. were significantly less worried about surgery, however, subset continued experience significant specific Women underwent when premenopausal worsening vasomotor symptoms decline functioning. Hormone replacement therapy mitigated these but pre-surgical levels. Dyspareunia somewhat alleviated hormone therapy, pleasure not. Satisfaction decision undergo high regardless symptoms. These studies will provide considering information possible