Etanercept allergy and anaphylaxis.

摘要: To the Editor: Etanercept has been an effective, well tolerated medication with uncommon and usually acceptable adverse effects. We are aware of only 4 reports describing possible/probable etanercept allergy/anaphylaxis1,2,3,4,5. describe 2 patients allergic/anaphylactoid reactions to etanercept, review literature, comment on pertinent management issues. A 49-year-old woman a history atopy anaphylactoid/angioedematous symptoms soy milk developed rheumatoid arthritis (RA) in 2009. She was started prednisone, minocycline, sulfasalazine, ibuprofen, hydroxychloroquine, poor response. then prescribed 50 mg weekly subcutaneously, which rendered her asymptomatic. However, after several months she reported increasingly frequent severe episodes characterized by urticaria swelling periorbital regions tongue within hours following administration requiring diphenhydramine, epinephrine, corticosteroids. Etanercept discontinued there no recurrence these events. A 27-year-old presented 2005 persistent rash, fevers, … Address correspondence Dr. R.S. Panush, 2011 Zonal Ave., HMR 711, Keck School Medicine, University Southern California, Los Angeles, CA 90032, USA. E-mail: panush{at}usc.edu