Anaphylaxis Induced by Biologics

摘要: Biologic agents are increasingly utilized in the medical management of many conditions. Their safety has become an important topic as a myriad reactions can occur due to immune-modulating properties these agents. Of these, anaphylaxis remains substantial concern, but its incidence and pathophysiology have not been comprehensively reviewed. Over past two decades, multitude case reports series published describing anaphylactic biologic agents, although true prevalence unknown for vast majority them. Based on cytokine mediator profiles, three mechanisms proposed: IgE-mediated, non-IgE-mediated, release. The clinical presentation is highly variable between degree humanization, excipient involvement, development process each agent all likely play role determining level allergenicity. As even more commonplace healthcare, thorough evaluations induced by BAs well underlying may provide clinically useful data when most appropriate option.