Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

摘要: Mast cells (MCs), which are granulated tissue-resident of hematopoietic lineage, contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However, MCs best known for their roles in allergic inflammatory diseases, such as anaphylaxis, food allergy, rhinitis, itch, urticaria, atopic dermatitis, asthma. In addition the high-affinity IgE receptor (FceRI), express numerous G protein-coupled receptors (GPCRs), largest group membrane proteins most common targets drug therapy. Antimicrobial host defense peptides, neuropeptides, major basic protein, eosinophil peroxidase, many US Food Drug Administration-approved peptidergic drugs activate human through a novel GPCR Mas-related X2 (MRGPRX2; formerly MrgX2). Unique features MRGPRX2 that distinguish it from other GPCRs include presence both on plasma intracellular sites selective expression MCs. this article we review possible defense, drug-induced anaphylactoid reactions, neurogenic inflammation, pain, chronic urticaria We propose peptides kill microbes directly could serve modulate against microbial infection. Furthermore, mAbs or small-molecule inhibitors be developed treatment MC-dependent disorders.