In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

摘要: Drug hypersensitivity reactions (DHR) are immune-mediated idiosyncratic adverse drug events. Type I DHR often referred to as "immediate" and involve B lymphocyte-secreted IgE that bind the membrane of basophils mast cells, inducing their degranulation. This review presents various in vitro tests were developed field human type HS implemented clinical diagnostic tools cases immediate DHR. The respective strengths weaknesses each test will be discussed parallel validation data such specificity sensitivity whenever available. Some them have also been used veterinary medicine, but not Most these can categorized into humoral cellular tests. former measure serum concentrations factors, histamine, tryptase, drug-specific IgE. latter assays quantify markers drug-induced basophil activation or lymphocyte proliferation. Pharmacogenetic investigated DHR, extensively non-immediate ones. Throughout, practical aspects limitations tests, well parameters, presented. In addition, experience medicine with summarized. However, date, none has ever reported a case