Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene

摘要: It is becoming increasingly clear that the activation of specific terminal differentiation genes during neural development critically dependent upon establishment unique combinatorial transcription factor codes within distinct cell subtypes. However, it still unclear to which extent these are shared by lineage-unrelated neurons expressing same genes. Additionally, not known if a gene restricted cells born at particular developmental time point. Here, we utilize FMRFa expressed Ap4 and SE2 in Drosophila ventral nerve cord, explore issues depth. We find generated different progenitors use activate expression. temporal expression windows. Extending investigation include second gene, Leucokinin, similar results, suggesting might commonly gene. Furthermore, results imply temporally unrestricted.