Multiplicity of mechanisms of serotonin receptor signal transduction
作者： John R. Raymond , Yurii V. Mukhin , Andrew Gelasco , Justin Turner , Georgiann Collinsworth
DOI: 10.1016/S0163-7258(01)00169-3
关键词: Biology 、 Metabotropic receptor 、 Signal transduction 、 Rhodopsin-like receptors 、 Receptor 、 Class C GPCR 、 Cell biology 、 Biochemistry 、 G protein-coupled receptor 、 Chemokine receptor 、 5-HT receptor 、 Pharmacology (medical) 、 Pharmacology
摘要: The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those characterized overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or editing, creates at least 20 more 5-HT receptors, that there are 30 distinct signal through G-proteins. This review will focus on what is known about the signaling linkages G-protein-linked highlight some fascinating new insights receptor signaling.
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