IMMUNOBIOLOGY OF CHILDHOOD TUBERCULOSIS: A WINDOW ON THE ONTOGENY OF CELLULAR IMMUNITY
作者： Sherilyn Smith , Richard F. Jacobs , Christopher B. Wilson
DOI: 10.1016/S0022-3476(97)70120-3
关键词: Cellular immunity 、 Pediatrics 、 Developing country 、 Immunology 、 Human immunodeficiency virus (HIV) 、 Childhood tuberculosis 、 Medicine 、 Tuberculosis 、 El Niño 、 Mycobacterium tuberculosis 、 Disease
摘要: Worldwide, Mycobacterium tuberculosis causes more deaths than any other organism. It is estmated that 1.7 billion people are infected with M. tuberculosis; the majority of those reside in developing countries. also estimated 60 million worldwide have active tuberculous disease and 2.6 to 2.9 die annually tuberculosis. 1 The emergence human immunodeficiency virus epidemic has contributed resurgence worldwide, 2 HIV infection currently one most important risk factors for progression from clinical disease. In 1990 it was 4.6% all were related HIV. 3 As global burden increases, number children will continue rise, 1.3 new cases < 15-year-old age group years 1994 1995.1 Although (defined as caused byM.. tuberculosis) occur world, reported United States increased late 1980s early 1990s. During 1995 there 22,813 States, occurring both foreign-born persons born States. 4 This figure may not fully reflect overall individuals, because without reportable only four states. recent data indicate a decrease total lastyear decreased younger 15 age.
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