Impact of ascorbic acid on selenium-induced growth inhibition of canine mammary tumor cells in vitro

摘要: Abstract Ascorbic acid (50 or 125 μmol/L) accentuated the in vitro growth inhibition of canine mammary tumor cell line 13 (CMT-13) induced by sodium selenite (12.6 μmol/L). While selenate was less effective than inhibiting these cells, its inhibitory effect also amplified supplemental ascorbic acid. did not modify anti-proliferative effects selenomethionine. Both and D-isoascorbic (an ascorbate analogue without anti-scorbutic properties) were equally increasing toxic against CMT-13 cells. (125 increased cellular selenium retention. These data show that antitumorigenic can be enhanced a related reducing compound.