Localization of neuronal and glial glutamate transporters
作者： Jeffrey D. Rothstein , Lee Martin , Allan I. Levey , Margaret Dykes-Hoberg , Lin Jin
DOI: 10.1016/0896-6273(94)90038-8
关键词: Glutamate homeostasis 、 Glutamate aspartate transporter 、 Neuroscience 、 Deep cerebellar nuclei 、 SLC1A1 、 Glutamate Plasma Membrane Transport Proteins 、 Glutamate reuptake 、 Biology 、 Hippocampus 、 Excitatory Amino Acid Transporter 3
摘要: Abstract The cellular and subcellular distributions of the glutamate transporter subtypes EAAC1, GLT-1, GLAST in rat CNS were demonstrated using anti-peptide antibodies that recognize C-terminal domains each transporter. On immunoblots, specifically proteins 65–73 kDa total brain homogenates. Immunocytochemistry shows are distributed differentially within neurons astroglia. EAAC1 is specific for certain neurons, such as large pyramidal cortical Purkinje cells, but does not appear to be selective glutamatergic neurons. GLT-1 localized only found both regional localizations unique taeach subtype. highly enriched cortex, hippocampus, caudate-putamen confined preand postsynaptic elements. astrocytes throughout spinal cord. most abundant Bergmann glia cerebellar molecular layer brain, also present deep nuclei.
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