Diverticular Disease of the Colon Does Not Increase Risk of Repeat C. difficile Infection

摘要: BACKGROUND Studies have suggested that colonic diverticulosis might increase the likelihood of repeat Clostridium difficile infection (CDI). Our study was designed to compare rates in patients with and without colon diverticula. METHODS Patients who had a positive C. toxin assay colonoscopic evidence were classified as CDI (CDI-D), whereas those but no such (CDI-ND). Various clinical epidemiologic factors recorded for each patient. Primary outcomes "relapse" (repeat within 3 mo initial infection) "recurrent" CDI≥3 after infection). Secondary 30 days diagnosis mortality, intensive care unit transfer, continuous hospitalization. RESULTS A total 128 CDI-D, 137 CDI-ND. There significant differences between CDI-D CDI-ND when comparing frequencies its subclassifications, relapse or recurrence. were, however, statistical associations seen ascending increased recurrence [hazard ratio (HR): 1.4±0.38, P<0.05] decreased diverticular disease descending (HR: 0.40±0.46, P<0.05), sigmoid 0.39±0.49, P<0.05). The association is limited by small patient population. any 30-day including requirement, hospitalization stay, mortality. CONCLUSIONS are not at risk CDI.