The Free Radical Theory of Aging
作者： Denham Harman
DOI: 10.1089/152308603770310202
关键词: Risk of death 、 Chemistry 、 Maximum life span 、 Free-radical theory of aging 、 Disease 、 Risk factor 、 Gerontology 、 Mortality trends 、 Clinical biochemistry 、 Cell biology 、 Biochemistry 、 Physiology 、 Molecular biology
摘要: Aging is the accumulation of changes that increase risk death. can be attributed to development, genetic defects, environment, disease, and an inborn process: aging process. The latter major factor for disease death after age 28 in developed countries. In these countries, average life expectancies at birth (ALE-B) now range from 76 79 years, 6-9 years less than limit approximately 85 imposed by aging. may caused free radical reactions. extensive studies based on this possibility hold promise ALE-B extended >85 maximum span increased.
liebertonline.com参考文章(130)
PHILIP L. HARRIS, NORRIS D. EMBREE, Quantitative Consideration of the Effect of Polyunsaturated Fatty Acid Content of the Diet Upon the Requirements for Vitamin E The American Journal of Clinical Nutrition. ,vol. 13, pp. 385- 392 ,(1963) , 10.1093/AJCN/13.6.385
C. Julian Rosenthal, Lee Sullivan, Serum Amyloid A Journal of Clinical Investigation. ,vol. 62, pp. 1181- 1186 ,(1978) , 10.1172/JCI109237
Benjamin N. Berg, Henry S. Simms, Nutrition and longevity in the rat. II. Longevity and onset of disease with different levels of food intake. Journal of Nutrition. ,vol. 71, pp. 255- 263 ,(1960) , 10.1093/JN/71.3.255
SARA VIA, Are We Alone Annals of the New York Academy of Sciences. ,vol. 950, pp. 225- 240 ,(2001) , 10.1111/J.1749-6632.2001.TB02141.X
Lee W. Wattenberg, Inhibition of Chemical Carcinogen-Induced Pulmonary Neoplasia by Butylated Hydroxyanisole JNCI: Journal of the National Cancer Institute. ,vol. 50, pp. 1541- 1544 ,(1973) , 10.1093/JNCI/50.6.1541
J. Tinoco, M. A. Williams, I. Hincenbergs, R. L. Lyman, Evidence for Nonessentiality of Linolenic Acid in the Diet of the Rat The Journal of Nutrition. ,vol. 101, pp. 937- 945 ,(1971) , 10.1093/JN/101.7.937
Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin Journal of the National Cancer Institute. ,vol. 48, pp. 1425- 1430 ,(1972) , 10.1093/JNCI/48.5.1425
A.J. Lea, DIETARY FACTORS ASSOCIATED WITH DEATH-RATES FROM CERTAIN NEOPLASMS IN MAN The Lancet. ,vol. 288, pp. 332- 333 ,(1966) , 10.1016/S0140-6736(66)92615-8
J. Epstein, S. Himmelhoch, D. Gershon, Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage Mechanisms of Ageing and Development. ,vol. 1, pp. 245- 255 ,(1972) , 10.1016/0047-6374(72)90070-X
S. Leto, M. J. Yiengst, C. H. Barrows, The Effect of Age and Protein Deprivation on the Sulfhydryl Content of Serum Albumin Journal of Gerontology. ,vol. 25, pp. 4- 8 ,(1970) , 10.1093/GERONJ/25.1.4