Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

摘要: Abstract The free-living nematode Caenorhabditis briggsae was used as a model for the study of phenomenon ageing. Electronmicroscopical examination cross-sections through animals different ages revealed severe damage to certain tissues aged . Progressive age-dependent accumulation pigment granules containing acid phosphatase activity demonstrated in intestinal epithelium ageing animals. It is suggested that these are age-pigment which product peroxidation cellular constituents. These eventually occupy most cytoplasmic volume and appear lead breakdown entire tissue. At terminal period animal's life, extensive body muscle cells nerve complexes observed.