Biological Functions of the ING Proteins.

摘要: The proteins belonging to the inhibitor of growth (ING) family serve as epigenetic readers H3K4Me3 histone mark active gene transcription and target acetyltransferase (HAT) or deacetylase (HDAC) protein complexes, in order alter local chromatin structure. These multidomain adaptor interact with numerous other facilitate their localization regulation biochemical pathways that impinge upon biological functions. Knockout some ING genes murine models by various groups has verified status tumor suppressors, ING1 knockout resulting formation large clear-cell B-lymphomas ING2 increasing frequency ameloblastomas, among phenotypic effects. ING4 strongly affects innate immunity angiogenesis, INGs1, ING2, have been reported affect apoptosis different cellular models. Although ING3 ING5 knockouts yet be published, preliminary reports indicate results embryonic lethality may postpartum effects on stem cell maintenance. In this review, we compile known information domains INGs altering expression, better understand functions its possible uses for targeted cancer therapy.