Longitudinal studies of immune function in cattle experimentally infected with bovine immunodeficiency-like virus and/or bovine leukemia virus

摘要: The effects of single or dual infection with bovine immunodeficiency-like virus (BIV) and/or, leukemia (BLV) on immune function were examined over a 4 year period. Holstein calves infected BIV (four calves), BLV (five and sham inoculated (three calves). Lymphocyte blastogenesis to mitogens, seven tests neutrophil function, mononuclear cell subset analysis by flow cytometry (BoCD4, BoCD8, BoCD2, BoWC1, sIgM+, monocytes) performed at regular intervals 49 months post-infection. These data analyzed for main each interaction as 2 x factorial. cattle had lower antibody-dependent cell-mediated cytotoxicity iodination responses during the years post-infection (P < 0.05). was not associated any long-term significant changes in lymphocyte mitogens numbers blood. There tendency animals alone have decreased blastogenic but this statistically significant. caused an increase total cells no dramatic shift relative proportions various subsets. Co-infection did consistently cause different response than either individually. One animal died non-BLV lymphosarcoma 7 after infection. All other unusual clinical signs. In summary, significant, temporary decrease consistent alteration first numbers, there appeared be synergism between viruses.