Heterogeneity of Pathogenetic Mechanisms in Aplastic Anemia

摘要: The mechanisms responsible for the bone marrow failure in 21 aplastic anemia patients were studied by colony-forming units culture assay (CFU-C). Twelve had no detectable in-vitro defect that could be low CFU-C numbers. Three suppressor T cells inhibited (p less than 0.001); one of two responded to antithymocyte globulin therapy and third recovered spontaneously. serum inhibitory immunoglobulins directed against their CFU-C; plasmapheresis resulted recovery function. abnormalities at colony-stimulating factor level: Two inhibitors factor, corrected vitro vivo indomethacin cholinergic agonists 0.01); generation defect, lithium. Testing cellular or humoral factors precursor level gives helpful guidelines anemia.