Genomic profiling of genes contributing to metastasis in a mouse model of thyroid follicular carcinoma.

摘要: Metastasis is the major cause of thyroid cancer-related death. However, little known about genes involved in metastatic spread carcinomas. We have created a mouse that spontaneously develops follicular carcinoma (FTC). This harbors targeted mutation (denoted TRβPV) hormone receptor β gene (ThrbPV/PV mice). Our recent studies show highly elevated level stimulating (TSH) ThrbPV/PV mice promotes proliferation tumor cells, but requires collaboration oncogenic action TRβPV to empower cells undergo distant metastasis. To uncover destined drive process, we used cDNA microarrays compare genomic expression profile laser capture microdissected lesions with hyperplastic wild-type having TSH induced by treatment anti-thyroid drug propylthiouracil (WT-PTU Analyses microarray data indicated expressions 150 were significantly altered between and WT-PTU (87 had higher 63 lower than Thirty-six percent function as key regulators The remaining various cellular processes including metabolism, intracellular trafficking, transcriptional regulation, post-transcriptional modification, cell-cell/extracellular matrix signaling. present uncovered novel responsible for FTC and, furthermore, shown process cancer effective among diverse functions. Importantly, indicate primary are endowed promote Thus, our study has provided new insights into understanding human cancer.