Increased T-allele frequency of 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene in differentiated thyroid carcinoma.

摘要: Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved folic acid metabolism and plays essential role inherited profiles. common 677 C>T 1298 A>C polymorphisms MTHFR cause production a thermolabile enzyme reduced function and, eventually, genomic hypomethylation. current preliminary study was designed to determine association between germ-line polymorphism differentiated thyroid carcinoma (DTC). Methods: In case-control 60 carcinomas (TC); 45 papillary TC, 9 follicular 6 DTC uncertain malignant potential were examined. Genomic extracted from peripheral blood EDTA, genotyped by multiplex real-time polymerase chain reaction. Results: An elevated 2.33-fold observed for individuals 677T...