Taurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance
作者： Gui-Ian Ye , Andrew C.O. Tse , Wing-ho Yung
DOI: 10.1016/S0006-8993(96)01427-8
关键词: Midbrain 、 Chloride channel 、 Bicuculline 、 Taurine 、 Biochemistry 、 Glycine 、 Biophysics 、 Strychnine 、 Patch clamp 、 Substantia nigra 、 Chemistry
摘要: Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 microM-10 mM) reversibly hyperpolarized and inhibited the firing substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA glycine. Strychnine competitively antagonized actions glycine but not GABA. On other hand, responses to sensitive bicuculline. findings suggest inhibits SNR neurons opening glycine-linked channels.
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sci-hub.se 参考文章(20)
Arne Schousboe, Clara Lopez Apreza, Herminia Pasantes-Morales, GABA and taurine serve as respectively a neurotransmitter and an osmolyte in cultured cerebral cortical neurons. Advances in Experimental Medicine and Biology. ,vol. 315, pp. 391- 397 ,(1992) , 10.1007/978-1-4615-3436-5_47
DL Martin, V Madelian, B Seligmann, W Shain, The role of osmotic pressure and membrane potential in K(+)-stimulated taurine release from cultured astrocytes and LRM55 cells The Journal of Neuroscience. ,vol. 10, pp. 571- 577 ,(1990) , 10.1523/JNEUROSCI.10-02-00571.1990
AA Grace, SP Onn, Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro The Journal of Neuroscience. ,vol. 9, pp. 3463- 3481 ,(1989) , 10.1523/JNEUROSCI.09-10-03463.1989
Katsuo Kamata, Tsutomu Kameyama, Shigeru Okuyama, Sanae Hashimoto, Hironaka Aihara, Contralateral circling behavior induced by intranigral microinjections of taurine and GABA in rats. Brain Research. ,vol. 343, pp. 275- 282 ,(1985) , 10.1016/0006-8993(85)90745-0
G. J. Stuart, H. U. Dodt, B. Sakmann, Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy Pflügers Archiv: European Journal of Physiology. ,vol. 423, pp. 511- 518 ,(1993) , 10.1007/BF00374949
Christopher S. Biggs, Leslie J. Fowler, Peter S. Whitton, Michael S. Starr, Impulse-dependent and tetrodotoxin-sensitive release of GABA in the rat's substantia nigra measured by microdialysis Brain Research. ,vol. 684, pp. 172- 178 ,(1995) , 10.1016/0006-8993(95)00281-T
Michel H. Bureau, Richard W. Olsen, Taurine acts on a subclass of GABAa receptors in mammalian brain in vitro European Journal of Pharmacology: Molecular Pharmacology. ,vol. 207, pp. 9- 16 ,(1991) , 10.1016/S0922-4106(05)80031-8
M.C. Doretto, R.L. Burger, P.K. Mishra, N. Garcia-Cairasco, J.W. Dailey, P.C. Jobe, A microdialysis study of amino acid concentrations in the extracellular fluid of the substantia nigra of freely behaving GEPR-9s : relationship to seizure predisposition Epilepsy Research. ,vol. 17, pp. 157- 165 ,(1994) , 10.1016/0920-1211(94)90015-9
Michael Häusser, Greg Stuart, Claudia Racca, Bert Sakmann, Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons Neuron. ,vol. 15, pp. 637- 647 ,(1995) , 10.1016/0896-6273(95)90152-3
Antoine Depaulis, Marguerite Vergnes, Christian Marescaux, Endogenous control of epilepsy: The nigral inhibitory system Progress in Neurobiology. ,vol. 42, pp. 33- 52 ,(1994) , 10.1016/0301-0082(94)90020-5