Helicobacter pylori as a prognostic indicator after curative resection of gastric carcinoma: a prospective study.

摘要: Summary Background The effect of Helicobacter-pylori status on survival after curative resection for gastric adenocarcinoma is unknown. We aimed to follow-up patients who were positive or negative infection with H pylori had (ie, R0) assess differences in relapse-free and overall survival. Methods Before surgery, we assessed the 166 R0 between 1992 2002 bacterial culture, histological analyses staining haematoxylin eosin Warthin-Starry), serological analyses. Findings At a median 53·0 months (range 1–146), was 56·7 (95% CI 4·7–108·7) 61·9 (13·0–110·9) , compared 19·2 (12·7–25·6) (7·1–31·3), respectively, (p=0·0009 difference groups, p=0·0017 groups). In multivariate analyses, an independent prognostic factor (hazard ratio 2·16 [95% 1·33–3·49]) (2·00 [1·22–3·27]). Depth tumour invasion (2·60 [1·66–4·08]), lymph-node metastasis (2·11 [1·25–3·57]), patient age 67·5 years older (1·75 [1·11–2·75]) also factors Interpretation Tumour-specific immune responses might be downregulated are these should followed up carefully because poor outlook.