Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

作者: Ikuo Takeda , Shoji Ine , Nigel Killeen , Lishomwa C. Ndhlovu , Kazuko Murata

DOI: 10.4049/JIMMUNOL.172.6.3580

关键词:

摘要: The OX40 (CD134) molecule is induced primarily during T cell activation and, as we show in this study, is also expressed on CD25+ CD4+ regulatory T (Treg) cells. A necessary role for …

参考文章(60)
Ethan M. Shevach, CD4+CD25+ suppressor T cells: more questions than answers Nature Reviews Immunology. ,vol. 2, pp. 389- 400 ,(2002) , 10.1038/NRI821
Ed C. Lavelle, Edel McNeela, Michelle E. Armstrong, Olive Leavy, Sarah C. Higgins, Kingston H. G. Mills, Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation. Journal of Immunology. ,vol. 171, pp. 2384- 2392 ,(2003) , 10.4049/JIMMUNOL.171.5.2384
Eishi Baba, Yoshiaki Takahashi, Juliane Lichtenfeld, Reiko Tanaka, Atsushi Yoshida, Kazuo Sugamura, Naoki Yamamoto, Yuetsu Tanaka, Functional CD4 T Cells after Intercellular Molecular Transfer of OX40 Ligand Journal of Immunology. ,vol. 167, pp. 875- 883 ,(2001) , 10.4049/JIMMUNOL.167.2.875
Shimon Sakaguchi, Noriko Sakaguchi, Misako Itoh, Masanao Asano, Masaaki Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology. ,vol. 155, pp. 1151- 1164 ,(1995)
Castle Funatake, Keith W. Wegmann, Keith W. Wegmann, Andrew D. Weinberg, Ruth H. Whitham, Ruth H. Whitham, Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. Journal of Immunology. ,vol. 162, pp. 1818- 1826 ,(1999)
Lishomwa C. Ndhlovu, Naoto Ishii, Kazuko Murata, Takayuki Sato, Kazuo Sugamura, Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. Journal of Immunology. ,vol. 167, pp. 2991- 2999 ,(2001) , 10.4049/JIMMUNOL.167.5.2991
Joseph R. Maxwell, Andrew Weinberg, Rodney A. Prell, Anthony T. Vella, Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. Journal of Immunology. ,vol. 164, pp. 107- 112 ,(2000) , 10.4049/JIMMUNOL.164.1.107
Pratima Bansal-Pakala, Amha Gebre-Hiwot Jember, Michael Croft, Signaling through OX40 (CD134) breaks peripheral T-cell tolerance Nature Medicine. ,vol. 7, pp. 907- 912 ,(2001) , 10.1038/90942
P.R. Baum, R.B. Gayle, F. Ramsdell, S. Srinivasan, R.A. Sorensen, M.L. Watson, M.F. Seldin, E. Baker, G.R. Sutherland, K.N. Clifford, Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. The EMBO Journal. ,vol. 13, pp. 3992- 4001 ,(1994) , 10.1002/J.1460-2075.1994.TB06715.X
Vivianne Malmström, Deborah Shipton, Baljit Singh, Aymen Al-Shamkhani, Michael J. Puklavec, A. Neil Barclay, Fiona Powrie, CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice The Journal of Immunology. ,vol. 166, pp. 6972- 6981 ,(2001) , 10.4049/JIMMUNOL.166.11.6972