THE EFFECTS OF HOMOCYSTEINE ON PLASMA BIOCHEMICAL PARAMETERS AND AORTIC MATRIX METALLOPROTEINASES ACTIVITIES

摘要: Objective; Increased levels of physiological amino acid homocysteine (Hcy) in plasma is associated with the development cardiovascular, neuronal, and liver diseases.[1] Damage vascular wall aorta develops by exposure vessel to not yet degraded, toxically acting hcy, as occurs beginning arteriosclerosis.[2] Methods; Our investigation was performed two parts on 12 male wistar rats, 3-4 months old both. First we investigated relation between other biochemical parameters which related cardiovascular events: Total cholesterol (CT), HDL (HDL-C), LDL (LDL-C), triglyceride (TG). We employed 3 groups: (C) control. (Met) rats received methionine high doses (200mg/Kg/day), (Met-C) order potentiate atherogenic effect administred (1500mg/Kg/day). Lipid were measured, structural damage an analyzed histology. In second part, used (M) (1g/Kg/day), (H) Hcy (20mg/day) compare effects both aortic MMPs expression. Results & Conclusion: The results show that elevated increase synthesis, exerts angiotoxic action direct (loss endothelium, degeneration partly dissolution media cells), induce expression MMP-2, while MMP-9 expressed.