Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience.

摘要: Wilms tumor (or nephroblastoma), rhabdomyosarcoma, and medulloblastoma, common embryonal tumors in children, can occasionally occur adults, for whom survival is significantly inferior than pediatric patients. Available data on adults with consist of case or series reports. Among other factors, the unfamiliarity adult oncologists pathologists nephroblastoma consequent delays initiating appropriate risk-adapted chemotherapy may negatively influence outcomes. The decrement rhabdomyosarcoma has been attributed to lack centralized care, inconsistent use standard protocol-driven multimodal therapy, lower tolerance In children evidence from randomized clinical trials led risk-tailored therapies tuned histology, extent initial disease, biological features. Such refinements are still missing due similar studies that might provide same a different understanding regarding patients’ individual prognosis, treatment morbidity, quality life. Recent experiences have suggested applying adjusting protocols patients these feasible improve survival. Here, we an evaluation current management tumor, medulloblastoma arising adults. This review aims promote referral adolescents centers inclusion into protocols, specifically designed age group cooperation between oncologists.